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Cannabidiol is Better Anti-Inflammatory than Aspirin and Tramadol

Cannabidiol Better Anti-Inflammatory Than Aspirin and Tramadol


The FDA approving Epidiolex proves something we’ve been saying for decades – Cannabis has medical value.  A simple pubmed.com search for ‘cannabidiol’ yields over 2000 published studies proving CBD has medical value.  CBD’s most studied and exciting medical benefits may be 1) anti-inflammatory properties and 2) anti-anxiolytic properties.  Inflammation and Anxiety result in most health problems in America and even can cause each other.  Unregulated anxiety releases inflammatory cytokines that eventually can result in heart disease and neurodegenerative conditions.


Today we’re going to talk about some inflammation.  I found this paper a few years ago and have meant to write about what it says for a while because it’s so exciting.  There is a link to the full paper below if you want to nerd out and read it, but I’m going to sum up what they did and the results.  I’ll also highlight some of the “extra interesting” stuff.

Cannabidiol vs. Aspirin vs. Tramadol in the Anti-Inflammatory Cage Match

This study was done on mice.  The scientists injected small amounts of zymosan into the paws of the mice.  Zymosan is a chemical scientists use to illicit sterile and controlled inflammation.  They measure the inflammation using three metrics: measuring swelling, mechanically poking the paw, and measuring TNF-a levels in the mice.

After the mice’s paws were inflamed, they started giving the mice varying doses of cannabidiol, aspirin, and tramadol and began measuring the anti-inflammatory properties of each drug.

The results

The cannabidiol outperformed both aspirin and tramadol in both anti-inflammatory and anti-nociceptive properties.  Aspirin hung in there, tramadol basically didn’t help anything.

Takeaways and interesting points in this study:

  • The CBD was administered by intraperitoneal injection and orally. The benefits of CBD were more efficient with the intraperitoneal injection, with 5 mg CBD/ kg body weight.
  • Higher doses of CBD, 25mg/kg and 50mg/kg were less effective at stopping inflammation than 5 mg/kg. I thought that was interesting.
  • They did the experiment with pure CBD as well as whole plant CBD extract. As expected, the whole plant extract was about 5x more efficient than pure CBD.  With oral administration, it took about 50mg of pure CBD to get the same results of 10 mg whole plant extract.
  • The aspirin hung in there and performed well.
  • The tramadol didn’t do anything. I would recommend no one ever take tramadol for any reason.  It’s strangely addictive and doesn’t help with pain.  I don’t really even know why it exists and is still prescribed for anything.
  • All the lab results for the cannabis extracts used are in the paper.
  • There are a lot of good charts and stuff to look at in the paper too.

By:  Daniel Macris

Founder and CEO of the Halcyon Companies and Cerebradiol.


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